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Synopsis: Using the clinical history and simple, inexpensive laboratory tests, community-based outpatient neurologists were able to determine the cause of distal symmetric polyneuropathy in three-fourths of patients presenting with typical symptoms.
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Debate over the cardiovascular effects of COX-2 inhibitors has raged for more than a year since a special communication was published in JAMA last August suggesting an increase in cardiovascular events with rofecoxib (Vioxx). Now a large retrospect, the cohort study from the Tennessee Medicaid program seems to confirm the prothrombotic effects of rofecoxib, at least in high dose.
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Prolonged starvation causes Wernicke's encephalopathy in spite of oral thiamine supplementation, and permanent neurological deficits may result.
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Deep-brain stimulation (DBS) of the globus pallidus interna (GPi) is an FDA-approved treatment for certain types of dystonia, but previous studies have been limited by a small sample size and/or a lack of adequate controls.
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Patients with sentinel headaches occurring in the 4-week period prior to a subarachnoid hemorrhage have a 10-fold increase in early rebleeding. These patients may benefit from ultra-early treatment including aneurysm obliteration.
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Patients with coronary artery disease who have received intra-coronary, drug-eluding stents (DES) may benefit from longer courses of clopidogrel than is currently standard.
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Patients show reversible MRI signal abnormalities in the CA-1 sector of the hippocampal cornu ammonis early in the course of TGA. They are not correlated with any specific clinical or memory features of the episode.