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New Diagnostic Methods for Creutzfeldt-Jakob Disease
Synopsis: Novel noninvasive diagnostic tests for Creutzfeldt-Jakob disease (CJD; nasal brushings) and variant CJD (urinary prion proteins) are reported to be highly sensitive and specific in two recent studies.
Will New Approaches Help to Treat ALS?
Pharmacology Watch: High-Dose Rofecoxib Confirmed Prothrombotic, Study Shows
Debate over the cardiovascular effects of COX-2 inhibitors has raged for more than a year since a special communication was published in JAMA last August suggesting an increase in cardiovascular events with rofecoxib (Vioxx). Now a large retrospect, the cohort study from the Tennessee Medicaid program seems to confirm the prothrombotic effects of rofecoxib, at least in high dose.Pharmacology Watch: Forgot Your Ginkgo? Forget About It, Study Shows
Antipsychotics in Alzheimer's Patients: The CATIE-AD Study
Because of adverse effects, special care should be used when prescribing the atypical antipsychotic drugs for patients with dementia.Rolandic Epilepsy Surgery — Weighing the Risks
Surgery for epilepsy in and around sensory-motor cortex can be effective in controlling seizures, but mild post-operative neurological deficits are not uncommon in patients operated on after age 25.What is the Mechanism of Transient Global Amnesia?
Patients show reversible MRI signal abnormalities in the CA-1 sector of the hippocampal cornu ammonis early in the course of TGA. They are not correlated with any specific clinical or memory features of the episode.Pharmacology Watch
Patients with coronary artery disease who have received intra-coronary, drug-eluding stents (DES) may benefit from longer courses of clopidogrel than is currently standard.Clinical Briefs in Primary Care Supplement
Sentinel Headaches: Do they Predict Rebleeding after Subarachnoid Hemorrhage?
Patients with sentinel headaches occurring in the 4-week period prior to a subarachnoid hemorrhage have a 10-fold increase in early rebleeding. These patients may benefit from ultra-early treatment including aneurysm obliteration.