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The broad misconception that infectious diseases were fading as a medical concern with the development of antibiotics and vaccines was dashed in dramatic and tragic fashion in 1981 when the first cases of a strange new illness were reported among groups of gay men in New York, Los Angeles and San Francisco. The AIDS epidemic had begun.
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Checklists and clear protocols for clinical care have been highly successful in infection prevention and other fields, but can be easily undercut by a simple non-action: silence.
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It is estimated that there were approximately 219 million cases of malaria in the world in 2010 and 680,000 or these cases were fatal. The majority of deaths occur in children, most in Africa — with one dying every minute. Fourteen countries are estimated to account for 80% of deaths, with the Democratic Republic of the Congo and Nigeria accounting for 40% of total global malaria deaths.
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In this issue: Aspirin use and AMD risk; using NSAIDs and antihypertensive agents; and FDA actions.
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Saint S, et al, Perceived strength of evidence supporting best practices to prevent health care-associated infection: results from a national survey of infection prevention personnel. Am J Infect Control 2013;(41):100-106.
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Gane et al conducted a randomized open label trial of 40 patients with HCV genotype 2 or 3 infection which evaluated sofosbuvir 400 mg once daily plus ribavirin (RBV) for 12 weeks.
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Doernberg and colleagues sought to determine whether receipt of doxycycline was associated with protection from development of Clostridium difficile infection (CDI) in hospitalized patients being treated with ceftriaxone, a known high-risk antibiotic for CDI.
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Human metapneumovirus (HMPV) was only discovered about a decade ago and until this study the extent of the disease — particularly in the young — was not known.
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Despite notable advances in critical care medicine, mortality from severe sepsis remains unacceptably high. With current therapeutic strategies, nothing has proven more crucial than early and effective antibiotics.