Bacterial Infections
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Use of Doxycycline as Postexposure Prophylaxis to Prevent Bacterial Sexually Transmitted Infections
In an open-label, randomized study involving men who have sex with men and transgender women, the use of doxycycline within 72 hours of condomless sex was associated with a two-thirds reduction in the incidence of bacterial sexually transmitted infections as compared with those who received standard care.
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CDC Update on Candida auris Epidemiology 2019 to 2021
A recent report from the Centers for Disease Control and Prevention discusses the changing epidemiology of Candida auris between 2019 and 2021, including a 200% jump in screening cases from 2020 to 2021.
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First Oral Fecal Microbiota Product Wins FDA Approval
There is a new tool available in the battle against one of the most common healthcare-associated infections in the United States.
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Researchers Use Advanced Technology to Detect MIS-C
Scientists want to improve diagnostic techniques for multisystem inflammatory syndrome in children, which became a confounding problem during the COVID-19 pandemic.
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SER-109 Improves Quality of Life Compared to Placebo in Patients with Recurrent Clostridioides difficile Infection
A secondary analysis of a Phase III clinical trial found SER-109 improved health-related quality of life for patients with recurrent C. difficile infection compared to placebo through eight weeks.
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Adjunctive Corticosteroids in Patients with Severe Community-Acquired Pneumonia
A double-blind, randomized, controlled trial conducted at 31 French medical centers demonstrated adult patients with severe community-acquired pneumonia who were given hydrocortisone had a lower risk of death by day 28 compared with those who received placebo.
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Doxycycline Demonstrates Protection Against Sexually Transmitted Infections
Common antibiotic could be a key tool to help stem the rising tide of reported cases.
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Infectious Disease Alert Updates
How to Assess CLABSI in Outpatient Infusion Therapy; Does Wearing Glasses Reduce the Risk of SARS-CoV-2 Infection?
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Immortal Time Bias and Mortality Effects of 18F-FDG-PET/CT in Patients with Staphylococcus aureus Bacteremia
Staphylococcus aureus bacteremia is associated with high mortality and often is complicated by metastatic sites of infection that can be difficult to identify and control. Fluorine-18 fluoro-2-deoxy-D-glucose positron emission tomography/computed tomography has shown promise in some observational studies as an important diagnostic modality for detecting foci of infection and potentially guiding clinical management in ways that may lead to improved outcomes, including lower mortality. The validity of these findings has been questioned, however, due to the risk of significant bias.
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Dual Therapy Using Doxycycline and Azithromycin Is Superior to Monotherapy for Treating Severe Scrub Typhus
A multicenter, randomized, double-blind, controlled trial from India found dual therapy with intravenous doxycycline and azithromycin is more effective than either agent alone for treating severe scrub typhus.