Bacterial Infections
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Sulopenem Etzadroxil and Probenecid (Orlynvah)
The U.S. Food and Drug Administration has approved a combination of sulopenem and probenecid for the treatment of uncomplicated urinary tract infections.
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Preventing Recurrent UTI with Probiotics
About half of women experience urinary tract infection (UTI) during their lifetime, and around 20% to 25% will experience recurrent UTI (defined as three or more UTIs in a 12-month period or two UTIs in a six-month period). Those with two UTIs in a six-month period have a 50% chance of a third UTI. Repeated courses of antibacterials distort both intestinal and vaginal flora, further increasing the risk of urinary infection.
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Outpatient CAP Treatment in Adults: Narrower Spectrum Therapy Is Better Tolerated
Examination of a large database led to the conclusion that treatment of community-acquired pneumonia in outpatients with narrower-spectrum agents (macrolides or doxycycline) was associated with similar clinical outcomes but with a lower incidence of adverse effects when compared to broader-spectrum therapy.
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Aztreonam-Avibactam vs. Meropenem for Serious Gram-Negative Bacterial Infections
In this multinational, prospective, Phase III, randomized trial, aztreonam-avibactam was found to be a safe and effective option, when compared to meropenem with or without colistin, for treating complicated intra-abdominal infections, hospital-acquired pneumonia, and ventilator-acquired pneumonia caused by gram-negative bacteria.
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A Review of Throat Infections: Low-Acuity Disease
Sore throats are common pediatric chief complaints, with etiologies ranging from thrush to epiglottitis. All clinicians must be familiar with the diversity of causes from benign to life-threatening in order to decrease morbidity and mortality with a timely diagnosis.
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Pediatric Pneumonia, Diagnostic Uncertainty, and Communication
Community-acquired pneumonia is a common cause of hospitalization among children in resourced countries and is the leading cause of childhood death in lower-income countries. However, the diagnosis of pneumonia is fraught with uncertainty, and management practices vary widely. Clinician behaviors and attributes that engender trust in the face of diagnostic uncertainty have been documented.
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Diagnostic Uncertainty in Community-Acquired Pneumonia
A national retrospective cohort study from the Veterans Administration found a high rate of diagnostic discordance for patients admitted and discharged for community-acquired pneumonia (CAP). Improvement in the diagnosis of CAP is needed.
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Extensively Drug-Resistant Shigella on the Rise
The prevalence of Shigella resistant to azithromycin, ciprofloxacin, ceftriaxone, trimethoprim-sulfamethoxazole, and ampicillin is increasing.
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H. pylori Infection: A Warning Sign for Alzheimer’s Dementia
A large nested case-control cohort study of subjects aged 50 years and older found that clinically apparent Helicobacter pylori infection is associated with a moderately increased risk of developing Alzheimer’s disease.
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Using Doxycycline as Postexposure Prophylaxis to Prevent Bacterial Sexually Transmitted Infections
In an open-label, randomized study involving men who have sex with men and transgender women, using doxycycline within 72 hours of condomless sex was associated with a two-thirds reduction in the incidence of bacterial sexually transmitted infections vs. those who received standard care.