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High-dose loop diuretics are often necessary to reduce elevated filling pressures in patients with heart failure. However, they are known to activate neurohormonal mechanisms that may be harmful.
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Cardiac resynchronization therapy (CRT) is now accepted as a disease-modifying therapy in patients with heart failure, left ventricular dysfunction, and intraventricular conduction defects. In this paper, Sipahi and colleagues review the data on the benefits of CRT in relationship to baseline QRS duration.
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ACEI/ARB therapy for AS; safety alert issued for dronedarone; statins and cancer risk; nesiritide and heart failure; and FDA actions.
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The echocardiographic assessment of diastolic function of the left ventricle (LV) involves five measurements derived from two-dimensional imaging, pulsed Doppler, Color M-mode, and tissue Doppler. Not only is it complicated, but sometimes the measurements are discordant.
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Computed tomography (CT) imaging has progressed substantially in recent years, and we are now able to non-invasively image coronary artery disease in many patients.
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In this study, the authors attempt to develop a risk stratification score to predict bleeding in patients treated with warfarin oral anticoagulation.
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In patients with severe valvular aortic stenosis (AS), ascending aortic dilatation is common, and is thought to be due to the alterations in flow caused by the stenotic valve.
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The Clinical Outcomes Utilizing Revascularization and Aggressive Drug Evaluation (COURAGE) study showed that in patients with stable coronary artery disease (CAD) put on optimal medical therapy (OMT) that randomization to a percutaneous coronary intervention did not improve survival or prevent myocardial infarction.