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The echocardiographic assessment of diastolic function of the left ventricle (LV) involves five measurements derived from two-dimensional imaging, pulsed Doppler, Color M-mode, and tissue Doppler. Not only is it complicated, but sometimes the measurements are discordant.
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Computed tomography (CT) imaging has progressed substantially in recent years, and we are now able to non-invasively image coronary artery disease in many patients.
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In this study, the authors attempt to develop a risk stratification score to predict bleeding in patients treated with warfarin oral anticoagulation.
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In patients with severe valvular aortic stenosis (AS), ascending aortic dilatation is common, and is thought to be due to the alterations in flow caused by the stenotic valve.
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The Clinical Outcomes Utilizing Revascularization and Aggressive Drug Evaluation (COURAGE) study showed that in patients with stable coronary artery disease (CAD) put on optimal medical therapy (OMT) that randomization to a percutaneous coronary intervention did not improve survival or prevent myocardial infarction.
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The authors conclude that even short-term treatment with most NSAIDs was associated with increased risk of death and recurrent MI in patients with prior MI. Neither short- nor long-term treatment with NSAIDs is advised in this population, and any NSAID use should be limited from a cardiovascular safety point of view.
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Two new drugs for treatment of hepatitis C; NSAIDs and myocardial infarction risk; AIM-HIGH clinical trial stopped; and FDA actions.
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In this paper, Haines and his coauthors propose a scoring system to predict risks associated with implantable cardioverterdefibrillator (ICD) implant procedures.
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RE-LY randomized 18,113 patients to one of its three arms. In the entire study group, dabigatran 110 mg twice per day compared with warfarin was associated with lower risks of major bleeding (2.87% vs 3.57 %), intracranial bleeding (0.23% vs 0.76%), and life-threatening bleeding (1.24% vs 1.85%).