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In recent years there has been considerable interest in the utilization of biomarkers to assist in the prediction of risk for cardiovascular events, including mortality.
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Anthracyclines may produce cardiotoxicity by apoptosis and free radical formation. Carvedilol, in addition to being a nonselective beta-blocker and alpha 1 blocker, is antioxidant and antiapoptotic.
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Several important papers have been published in the last 2 months, none more important than the realization that breast cancer rates have dropped precipitously since the publication of the Women's Health Initiative (WHI) in 2002.
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In this paper Pappone and his colleagues report a randomized study comparing circumferential pulmonary vein ablation (CPVA) to antiarrhythmic drug therapy in patients with paroxysmal atrial fibrillation who had previously failed at least one trial with antiarrhythmic drugs.
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Patients with coronary artery disease who have received intra-coronary, drug-eluding stents (DES) may benefit from longer courses of clopidogrel than is currently standard.
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Significant reductions in door-to-balloon time for acute STEMI are accomplished by reducing the time required to activate the cardiac catherization lab.
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For defibrillation success there is no significant difference between monophasic and biphasic shocks.
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In the Framingham study non-HDL cholesterol is a stonger predictor of subsequent CHD than LDL cholesterol.