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Articles

  • Long-Term Outcome Poor After Prolonged Ventilator Weaning

    This large, single-center observational study found that 5-year survival of patients requiring prolonged mechanical ventilation and care at an in-patient hospital-based weaning unit was only 19%.
  • Operation Iraqi Freedom: Some Lessons Learned From the Gulf

    This is a personal account of military medicine in the recent conflict. It reflects a view from a relative newcomer to Navy medicineme. I learned many important lessons about providing medical care to the participants and bystanders of war, about the character of those involved in all areas of the conflict, and about myself.
  • Full February 2004 Issue in PDF

  • Pharmacology Watch: Valacyclovir Reduces Genital Herpes Transmission

    A once-a-day dose of a valacyclovir reduces the rate of transmission of genital herpes (HSV-2) from an infected partner to an uninfected susceptible partner, according to a new study.
  • Ways to improve genetic trials informed consent

    While an argument could be made that collecting genetic information from individuals is no different from collecting any other type of health information, the fact remains that the very word genetic may raise additional concerns among potential research participants.
  • Don’t be confused by the rules governing adverse event reporting

    Reporting rules for adverse events in clinical trials only seem straightforward in the case of death or injury requiring hospitalization. Otherwise, those involved in clinical trials have to figure out how soon they need to report, what information needs to be included in the report, and who should get it.
  • AE relationship to study product

    The possible relationship of an adverse event to use of study product is assessed by the investigator. The terminology for these assessments can vary from one reporting system to the next. The DMID (S)AE reporting system uses the following terms to describe the relationship of an AE to the study product.
  • Getting consent from non-English speakers

    According to the U.S. Census Bureau, in 2000, just under 18% of the population thats more than 46 million people spoke a language other than English at home. For researchers doing work that can apply across populations, that has one big implication: Minority groups need to be actively recruited for clinical studies; and since many dont speak English, informed consent documents should be translated into a language they can read and understand.
  • Parents often don’t understand research

    Imagine you had a very sick child and were approached about him or her being in a study. In your worry for your son or daughter, how much of the informed consent process would you understand? Would you be clear on what the study entailed? According to several studies published in the last year, maybe not.
  • Education vital in litigious clinical trial arena

    Right now in Seattle, a lawsuit is pitting families of five research patients against the Fred Hutchinson Cancer Research Center. At issue is whether leukemia patients participating in a study on T-cell depletion fully understood the risks of the proposed treatment and gave informed consent.