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Is Pimavanserin Safe to Use in Patients with Parkinson’s Disease?

This retrospective cohort study of patients with Parkinson’s disease ages 65 years or older residing in Medicare-certified long-term care facilities revealed pimavanserin use vs. nonuse is associated with an increased risk of 30-day hospitalization and higher 90-, 180-, and 365-day mortality.

Neurodegenerative Ataxia: Improvement in Motor and Cognitive Outcomes with Cerebello-Spinal Stimulation

Concurrent cerebellar and spinal stimulation with a transcranial direct current stimulation device resulted in improvement of both motor and cognitive functions in patients with several different forms of neurodegenerative ataxia.

Is the Suicidality Class Warning Warranted for Antiseizure Medications?

This study reports data that refutes the U.S. Food and Drug Administration’s class warning regarding suicidality risk in patients with epilepsy who are taking the newer antiepileptics, approved since 2008. The class warning should be reconsidered.

Atogepant for Migraine Prevention

Atogepant, an oral small-molecule inhibitor of the calcitonin gene-related peptide pathway, administered once daily, effectively reduced migraine days in the preventive treatment trial of migraine over a period of 12 weeks.

Vitamin D and COVID-19

Low levels of vitamin D are associated with in-hospital mortality in patients with COVID-19, but causality is not yet known.

Rapid Eye Movement Sleep Duration Is Predictive of Life Expectancy

Total sleep duration declines with older age, as does the fraction of sleep spent in rapid eye movement (REM) sleep. The decline in REM is associated with increasing mortality, but it is unclear if this is a cause or a marker of declining health and declining brain function.

Cannabis Use and Associated Health Conditions in Primary Care: An EHR Review

This cross-sectional review of 185,565 patients’ medical records revealed documentation of medicinal cannabis use in 2% of the records. Within this subgroup, 44.5% had documentation of one or more health conditions potentially benefitting from treatment with cannabis, 54.4% had documentation of one or more health conditions potentially worsening with cannabis use, and 36.6% had both types of health conditions.

Hypertension in Adults: An Update

Hypertension remains the leading cause of death and disability-adjusted life years globally, accounting for 10.4 million deaths per year. In the United States, hypertension accounts for more cardiovascular disease deaths than any other modifiable risk factor and is second only to cigarette smoking as a preventable cause of death for any reason.