-
Even as multicenter studies with central IRB reviews gain traction, some IRBs are still hesitant to join in. However, coordinating a multisite study among several IRBs within the same university system can be a time and paperwork hassle for both principal investigators and IRBs and could make previously reluctant IRBs consider a new central reliance agreement.
-
The Presidential Commission for the Study of Bioethical Issues May 2014 report, Gray Matters: Integrative Approaches for Neuroscience, Ethics, and Society, includes recommendations for institutions and individuals engaged in neuroscience research.
-
Technology advances have driven increased interest in molecular studies involving tissue analyses. As a result, biotech firms increasingly are asking scientists to sell human tissues for study by outside enterprises.
-
The IRB at Grand Valley State University in Allendale, MI, uses a matrix that clarifies how IRB members and staff might describe various potential harms at four levels, from no more than minimal risk to high risk.
-
During my final year of interventional cardiology training, a woman in her 60s was brought emergently to the cath lab in cardiogenic shock, with diffuse ST-segment elevations.
-
Patients on mechanical ventilation who were managed with both conservative fluid administration and aggressive diuresis weaned faster, had significantly more ventilator-free days, and experienced reduced incidences of both ventilator-associated complications and ventilator-associated pneumonia.
-
Compared to manual surveillance methods, an electronic surveillance tool for catheter-associated urinary tract infections had a high negative predictive value but a low positive predictive value.
-
A large, multicenter clinical trial that compared protocol-based care to usual care for patients presenting to emergency departments with early sepsis and septic shock found no differences in clinical outcomes. However, early recognition and therapy was beneficial and should be the standard of care.
-
In this large prospective study of trauma patients, the most important factor associated with post-traumatic seizures was the presence of alcohol intoxication.
-