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The "Caprisa 004" trial was a randomized double-blind controlled trial of 1085 sexually active, HIV-negative, high-risk women in South Africa over 2.5 years (889 women were included in the final analysis).
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Secondary recurrent miscarriage (defined as three or more pregnancy losses at < 20 weeks occurring in a women with a least one pregnancy carried beyond 20 weeks) may be explained by a chromosomal abnormality or be "unexplained" (idiopathic).
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Many clinicians are reluctant to give low-dose aspirin (ldasa) to pregnant women for the prevention of preeclampsia. This reluctance is not based on a fear of potential risk, but on inconsistent study results regarding the efficacy of ASA.
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The Certified IRB Professional (CIP) credential has gained considerable respect in its 10 years of existence, especially among research institutions seeking employees who have passed the CIP exam or who are willing to take the test as soon as they qualify.
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When the IRB faced a regulatory crisis period in the late 1990s, research institutions responded by putting more resources into human subjects protection and compliance, and the IRB world responded with the introduction in 2000 of the Certified IRB Professional (CIP) examination by Public Responsibility In Medicine and Research (PRIM&R) of Boston, MA.
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Trying to recruit people with medical conditions for research while maintaining their confidentiality can be a challenging task.
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The search for a female-controlled form of HIV prevention just took a giant step. Results of a Phase IIB trial of a tenofovir gel indicate that use of the gel before and after sex provided moderate protection against sexually transmitted HIV.
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Your next patient is a recently divorced 48-year-old mother of two. Her menstrual periods have become somewhat irregular, and she reports occasional hot flashes and night sweats.
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Good news! Scientists have discovered two potent human antibodies that can neutralize more than 90% of known global HIV strains from infecting human cells in the laboratory, and they have demonstrated how one of these disease-fighting proteins achieves this action.