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When a research network sets out to conduct multisite trials, IRBs can sometimes be seen as an obstacle that must be overcome.
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Each year the Council for Certification of IRB Professionals (CCIP) meet with representatives of the Professional Testing Corp. (PTC) to prepare the next year's Certified IRB Professional (CIP) examination.
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When a patient clicks on a link from the Web site of an organization such as KS&A to express an interest in participating in medical research, it sets off a chain of questions and choices that help that patient tailor the security to his or her own preferences.
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In this issue: Antiviral drugs and birth defects, bisphosphonates and esophageal cancer, naltrexone plus bupropion for weight loss, 2010-11 influenza vaccine, FDA Actions.
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This study from the University of Amsterdam reports outcome data on 105 consecutive patients resuscitated from primary cardiac arrest and treated in the ICU with a protocol of induced mild hypothermia.
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Management of patients with accidental or intentional poisoning in drug overdose is a common problem for the intensivist. The actual incidence of poisoning in the United States is unknown because of lack of adequate reporting, but a minimum of several million cases occur annually. The vast majority of these cases do not require ICU admission.
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In this secondary analysis of data from a study on the pre-extubation prediction of post-extubation work of breathing in patients recovering from acute respiratory failure, Mehta and colleagues sought to determine whether the size of a patient's endotracheal tube (ETT) affected respiratory rate, tidal volume, and other "weaning parameters" commonly measured during spontaneous breathing and used to predict successful extubation.
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The authors set out to compare arterial and central venous blood gases (ABG and VBG, respectively), to evaluate the utility and accuracy of a predefined algorithm for adjusting VBG pH and pCO2 to approximate that of ABG, and to define clinical scenarios where a VBG may not be a useful substitute for an ABG.