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Dual Antiplatelet Therapy With Cilostazol for Secondary Stroke Prevention (LB3)
In a recent trial, patients treated with dual antiplatelet therapy combining cilostazol with either aspirin or clopidogrel were at a lower risk of ischemic stroke recurrence and at a similar risk of significant bleeding compared to patients treated with aspirin or clopidogrel alone.
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IV to Oral Conversion of Antibiotic Therapy for Bacteremia Due to Enterobacteriaceae
Oral step-down antibiotic therapy (IV to oral conversion) is safe and effective in patients with bloodstream infection due to Enterobacteriaceae.
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Rethinking the Prophylactic Use of Proton Pump Inhibitors in the ICU
The authors of this multicenter, blinded, randomized trial found that among critically ill adults at risk for gastrointestinal (GI) bleeding, fewer patients in the pantoprazole group exhibited clinically important GI bleeding compared to placebo, although mortality at 90 days was similar in both groups.
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An Update to the Management of Atrial Fibrillation
This focused update to the 2014 guidelines for the management of atrial fibrillation (AF) includes revisions to anticoagulation recommendations and the role of catheter ablation of AF in patients with heart failure.
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Corticosteroid Administration in Sepsis May Be Associated With Lower 28-Day Mortality
In this systematic review and meta-analysis of randomized, controlled trials comparing administration of corticosteroids with placebo or standard supportive care in sepsis, corticosteroids were associated with reduced 28-day mortality.
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Using Ketamine in the Critically Ill: A Clinical Review
This is a guideline for ketamine use in the appropriate clinical setting from the practicing intensivist’s perspective.
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Management of Spontaneous Coronary Artery Dissection
In the largest study to date about patients with spontaneous coronary artery dissection who underwent follow-up angiography, 95% of those who underwent repeat cath more than 30 days later showed spontaneous angiographic healing.
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Impact of Atrial Fibrillation on Survival in Patients With Severe Mitral Regurgitation
A large observational study of patients with severe mitral valve regurgitation due to flail leaflets revealed that atrial fibrillation at entry was associated with excess mortality.
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Who Needs a TEE Prior to Atrial Fibrillation Cardioversion?
A study of patients with atrial fibrillation or flutter undergoing transesophageal echocardiography showed a left atrial appendage thrombus in 8% overall and 4% in those appropriately anticoagulated.
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Medication First? Ablation First? Either Way, Make Weight Loss a Priority
Weight loss management and aggressive risk factor modification associated with slowing or even reversal of atrial fibrillation progression.