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Staphylococcus aureus Bloodstream Infections in the United States
Although the rate of hospital-onset MRSA bacteremia has decreased since 2012, the rate of decrease has slowed. The National Action Plan goal of a 50% reduction by 2012 compared to 2015 seems out of reach.
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Corticosteroid Administration in Sepsis May Be Associated With Lower 28-Day Mortality
In this systematic review and meta-analysis of randomized, controlled trials comparing administration of corticosteroids with placebo or standard supportive care in sepsis, corticosteroids were associated with reduced 28-day mortality.
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When to Screen for and Treat Asymptomatic Bacteriuria
New guideline recommendations indicate that the only unequivocal indications for screening and treatment of asymptomatic bacteriuria are pregnancy and undergoing endoscopic urologic procedures associated with mucosal injury.
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Viruses, Food Allergies, and Childhood Wheezing
Infants with severe bronchiolitis sometimes develop subsequent recurrent wheeze and asthma. Among infants hospitalized with bronchiolitis, the risk of developing asthma is greatest in those with rhinovirus C infection, especially if they also are sensitized with IgE against foods.
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Oral Antibiotics Are Noninferior to Intravenous for Bone and Joint Infections
In a randomized, controlled trial of adult patients with bone or joint infections, researchers found oral antibiotic therapy was noninferior to intravenous therapy based on treatment failure at one year.
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Undetected Plague Exposes Hospital Workers
In an incident that could have implications for therapy and support dogs in healthcare, 116 employees and students in a veterinary teaching hospital were exposed to pneumonic plague by a dog with unrecognized infection, investigators report. -
Intervention Reduces MRSA in Non-ICU Patients With Devices
Routine chlorhexidine bathing and targeted use of mupirocin dramatically reduced methicillin-resistant Staphylococcus aureus (MRSA) infections in non-ICU patients with invasive devices like central lines, researchers report.
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Avoid Antibiotics by Reducing Unnecessary Urine Tests
Changing urine culture order test indications during a switch to a computerized physician order entry sharply reduced unnecessary cultures and saved considerable costs in lab expenses, researchers report. Moreover, it spared patients with asymptomatic bacteriuria from treatment more appropriate for a fully diagnosed urinary tract infection. -
Surgical Site Infections and the Patient Microbiome
Evidence is mounting that the vast majority of surgical site infections (SSIs) are caused by microorganisms on patients’ skin and in their nares, meaning intensifying and improving skin prep and nasal decolonization could greatly reduce SSIs. -
IPs Finally Moving the Needle on C. diff
A combination of antibiotic stewardship, infection prevention, and environmental cleaning contributed to a 20% reduction in Clostridioides difficile from 2016 to 2017, the Centers for Disease Control and Prevention reports.