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White Matter Hyperintensities and Progression of Parkinsonism in Older Adults
Both higher levels of cerebral white matter hyperintensities and cerebrovascular disease pathologies may be associated with a more rapid progression of parkinsonism in older adults.
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Rituximab Treatment for AChR Myasthenia Gravis: Results of the BeatMG Study
The B-Cell Targeted Treatment In Myasthenia Gravis (BeatMG) study was the first prospective, randomized, double-blind, placebo-controlled clinical trial to explore the role of targeted B-cell depletion in myasthenia patients. Although rituximab was found to be safe and well-tolerated, rituximab treatment did not confer a significant steroid-sparing effect compared to placebo. Results of a futility analysis suggested rituximab treatment would be unlikely to show a clinically meaningful improvement of 30% over placebo in a larger Phase III trial of mild to moderately symptomatic acetylcholine receptor autoantibody-positive generalized myasthenia gravis patients.
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Plasma Biomarkers for Neurodegenerative Dementias: We Are Getting Closer
Two recent multicenter studies suggest that plasma biomarkers, including phosphorylated-tau181, could be used as cost-effective and more readily accessible biomarkers for the diagnosis and management of individuals with neurodegenerative dementias.
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How Many Leads Are Abnormal?
The figure was obtained after cardiac catheterization for new chest pain. The rhythm is sinus bradycardia at ~50 beats/minute. All intervals are normal. The axis is leftward, but not enough to qualify as a hemiblock. There is no chamber enlargement.
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Abrocitinib Tablets/Upadacitinib Extended-Release Tablets (Cibinqo/Rinvoq)
Abrocitinib and upadacitinib can be prescribed to treat adults with refractory, moderate-to-severe atopic dermatitis that is not adequately controlled with other systemic drug products, including biologics, or when using those therapies is inadvisable.
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Booster Doses Effective Against Omicron
While vaccination provides protection against infection with omicron variant of SARS-CoV-2, high level protection from a need for hospitalization requires a booster dose.
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Association Between Breastfeeding and Blood Pressure at 3 Years of Age
Any breastfeeding, including within the first days of life, was associated with significantly lower systolic blood pressure at age 3 years in participants from the Canadian Healthy Infant Longitudinal Development Cohort Study.
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Infectious Disease Alert Updates
Delayed HIV Diagnosis with Injectable PrEP; Fatal Wave of COVID-Associated Mucormycosis
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How Certain Is a Negative Echocardiogram for Excluding Infective Endocarditis?
Applying the proposed strict negative criteria for infective endocarditis (IE) on the first echocardiogram indicated this approach largely prevented unnecessary repeat tests unless clinically indicated for continued suspicion of IE.
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Menstrual Toxic Shock Syndrome
The authors reviewed 102 patients with menstrual toxic shock syndrome requiring intensive care over 16 years in France. Despite the severity of illness, there were no deaths.