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Optimal Antithrombic Therapy After PCI for Atrial Fibrillation Patients
In three subgroups of coronary artery disease patients with atrial fibrillation, apixaban plus a P2Y12 inhibitor provided superior safety and similar efficacy outcomes as treatment with warfarin, aspirin, or both for six months.
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The Risk of Endocarditis With Bacteremia
Interrogation of the Danish National Patient Registry revealed bacteremia due to Enterococcus faecalis was most likely to be associated with infective endocarditis; thus, echocardiography is warranted in these patients.
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Aggressive Afterload Reduction Does Not Improve Outcomes in Acute Decompensated Heart Failure
The authors of the GALACTIC trial found no benefit from an aggressive vasodilation approach for patients hospitalized with acute decompensated heart failure.
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Subclinical Atrial Fibrillation Detected By Implanted Loop Recorders: Common, But How Burdensome?
In older patients with risk factors for stroke drawn from the general population, previously undiagnosed and asymptomatic episodes of atrial fibrillation are detected frequently via implantable loop recorder monitoring, allowing for early initiation of anticoagulation therapy.
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Stenting Nonculprit Lesions After STEMI: Long-Term Data Support Complete Revascularization
Data from the CvLPRIT trial of complete vs. culprit-only percutaneous coronary intervention in ST-segment elevation myocardial infarction (MI) show a significantly lower rate of major adverse cardiovascular events, all-cause mortality, and lower composite MI in the complete revascularization group at a median follow-up of 5.6 years.
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Deadly Pediatric Rashes
Rash is a common complaint in the emergency department (ED). Often, the pediatric rash is a benign, self-limiting condition that requires no intervention; however, there are occasions when rashes are true emergencies. Identifying these rare occasions is critical for the pediatric patient. This issue reviews and discusses some of the most common pediatric dermatologic emergencies and the ED approach to identification, diagnosis, and immediate evidence-based management of these conditions. -
CNS Agents Emerge as Frontrunners in FDA-Approved Treatments for Low Libido in Women
Low libido is the most common sexual complaint, affecting up to 38.7% of women, with up to 12.3% also reporting significant distress associated with this condition. In the past five years, for the first time in history, there are two Food and Drug Administration-approved medications specifically for treating hypoactive sexual desire disorder in women. Of note, both medications are central nervous system agents.
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Estrogen Replacement: Is Long Duration of Therapy Good for the Brain?
Longer lifetime exposure to endogenous estrogen and menopausal estrogen replacement were associated with better cognitive status in older adult women. Women who initiated estrogen therapy early (within five years of the onset of menopause) showed higher cognitive test scores than those who started later.
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Tenaculum Placement Techniques and Effect on Pain
In this randomized controlled trial, there was no difference in pain score with tenaculum placement between the slow method of application and coughing with application (median pain score 44 vs. 32, P = 0.16).
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What Are the Roles of the Combined Oral Contraceptive Pill and Metformin in the Management of Polycystic Ovary Syndrome?
This systematic review documents the effectiveness of combined oral contraceptive pills in treating hyperandrogenism and irregular menses, and of metformin in addressing the metabolic disturbances in women with polycystic ovary syndrome.