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Treating Ebola Virus Infection
Two monoclonal antibody preparations have been demonstrated to significantly reduce mortality in patients with Ebola virus infection.
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Preventing Ebola Virus Infection
In a scientific/public health triumph, the first vaccine for the prevention of Ebola virus infection has been approved. If administered prior to 10 days after exposure, its protective efficacy is 100%.
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Ebola in Democratic Republic of the Congo: Confronting Potential Disaster
The second largest outbreak of Ebola virus infection has come under control.
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Efficacy of Vitamin C Infusion on Outcomes in Sepsis-Induced ARDS
In this randomized, double-blinded, placebo-controlled trial, intravenous vitamin C infusion did not influence a change in the modified Sequential Organ Failure Assessment score from the time of infusion to four days compared to placebo.
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Longer Antibiotic Courses for Pneumonia Do Not Improve Outcomes, But Cause More Adverse Effects
Two-thirds of general medicine patients with pneumonia received excess antibiotic therapy, with 93.2% of the unnecessary duration occurring after hospital discharge. Excess antibiotic therapy did not improve mortality or morbidity outcomes, although each additional antibiotic day was associated with 3% increased odds of antibiotic-associated adverse drug events.
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Antimicrobial Stewardship in Critical Care
Antimicrobial stewardship is the responsibility of everyone involved in the care of critically ill and hospitalized patients. This review discusses some of the key principles and practices of successful antimicrobial stewardship programs, particularly as they relate to critical care.
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Healthcare Worker Attitudes About Respiratory Protection: It’s Complicated
In an unusual qualitative study, healthcare workers revealed a variety of attitudes about respiratory protection equipment, including motivations and suspicions that could improve or undermine compliance.
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Infectious Disease Update: Are You Looking for ESBLs?
Prevention strategies are necessary to limit transmission of multidrug-resistant organisms in the hospital, especially in high-risk settings. Identification of carriers of extended-spectrum beta-lactamase (ESBL)-producing organisms via active surveillance, and contact isolation of positives, has been recommended for certain high-risk groups.
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Antibiotic-Resistant Infections in Pediatrics
There are some signs of progress in drug-resistant infections in pediatrics, suggesting that antibiotic stewardship efforts may be having an effect and fewer broad-spectrum agents are being used on this important patient group, the Centers for Disease Control and Prevention reports.
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C. diff: Colonization and Consequences
Although once thought of almost exclusively as a hospital-acquired condition, Clostridioides difficile has established a presence in the community that means about 10% of incoming patients could be carrying it asymptomatically, a new study finds.