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Immune Cell Infiltration Drives Cerebral Edema in Glioblastoma
Accumulating evidence suggests that immune dysregulation by glioblastoma cells induces tumor-associated edema and that disruption of this tumor-immune interaction may represent a novel strategy to reduce cerebral edema in glioblastoma.
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Lifetime Risk and Heritability of Amyotrophic Lateral Sclerosis
In this prospective, population-based study, mean lifetime heritability of amyotrophic lateral sclerosis was 52% in the entire cohort and 37% in patients devoid of any known pathogenic mutations. The highest heritability was seen in mother-daughter parings in both groups.
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Spontaneous Anterior Interosseous Nerve Syndrome
Anterior interosseous nerve syndrome is part of the median neuropathy spectrum and often has been attributed to compression near the elbow. Modern magnetic resonance neurography and ultrasound studies have ruled-out compression in most cases.
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Diagnostic Criteria for Small Fiber Neuropathy
Multiple clinical tools have emerged to assess small fiber nerve dysfunction, but validated diagnostic criteria are needed to optimize diagnostic sensitivity, support clinical management, and facilitate patient selection for clinical trials.
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Pitfalls in Treating Hand Emergencies
Traumatic and nontraumatic conditions involving the hand are among the more common clinical events seen in emergency departments. This article reviews the pitfalls that clinicians who encounter acute hand conditions must navigate successfully.
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Social Media Effective Tool to Recruit Youth for Research Studies
Researchers are turning to social media to recruit participants, with a recent study revealing that Instagram and Snapchat are effective ways to reach youth.
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Chinese Gene Edit Researcher Receives Three-Year Sentence
A rogue scientist who shocked the research community by genetically editing human embryos has been sentenced to three years in prison in China, according to the state-run press.
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IRB Teaches Research Teams How to Write Key Informed Consent Information
The revised Common Rule charged IRBs with writing concise and focused informed consent information. The challenge for IRBs is how to achieve this. The Colorado Multiple IRB at the University of Colorado has found a novel solution: The IRB trained staff on how to write key information consistently. They also added these tasks to the IRB staff’s workload without delaying IRB reviews, or having to use additional staff resources.
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Pregnant Women Face ‘Default’ Exclusion From Clinical Trials
With the revised Common Rule removing pregnant women from the list of “vulnerable populations” in 2019, it is time for IRBs to reconsider the default exclusion of expectant mothers from clinical trials, a bioethicist argued in a new paper.
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Building Foundational Trust Among Minority Populations Is First Step
Lack of trust is an important issue affecting recruitment of underrepresented minorities in research studies. When there is little trust for medical and research professionals among a particular underrepresented minority group, it is important for research organizations to build a foundation for trust before recruiting people for a particular study. Trust issues can be ingrained in the culture, or based on individuals’ personal experiences in healthcare.