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Using Apple Cider Vinegar for Weight Management on a Restricted Diet
Supplementation with 30 mL of apple cider vinegar combined with a restricted calorie diet may decrease body weight, body mass index, and serum triglyceride levels in people with obesity.
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Are Epidural Steroid Injections Cost-Effective?
In a retrospective review of patients treated for low back pain and lumbar radiculopathy at the Cleveland Clinic, at three- and six-month follow-up, epidural steroid injections were no better than conservative therapies in quality of life measures or overall cost of medical care.
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Mindfulness Interventions for ADHD: Neurobiologic Antidote?
The current standard of care consists of behavioral interventions and stimulant medication; however, symptoms often are recalcitrant to these therapies and medication treatment has significant potential for undesirable effects. Functional neuroimaging studies support the premise that functional connectivity abnormalities in attention deficit hyperactivity disorder brains may be targeted directly and improved by mindfulness and meditation interventions.
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Cavum Septum Pellucidum and Cavum Vergae: Markers of Chronic Brain Injury?
A cohort study assessing participants from the Professional Fighters Brain Health Study found that the presence of cavum septum pellucidum and cavum vergae is associated with lower regional brain volumes and lower cognitive performance.
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Intravenous Immunoglobulin for Treatment of Autoimmune Epilepsies
Patients with LGI1 and CASPR2 IgG-associated autoimmune epilepsy were identified and randomized to treatment with intravenous immunoglobulin (IVIG) vs. placebo. The authors hypothesized that IVIG would show superiority over placebo, with a primary endpoint of 50% or greater seizure reduction.
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Rituximab for the Treatment of MOG and AQP4 Antibody Diseases
Based on an observational prospective study of 16 patients with anti-myelin oligodendrocyte protein (MOG) disease and 29 anti-aquaporin-4 disease, the authors report lesser efficacy of rituximab in anti-MOG patients, characterized by higher occurrence of relapses in the anti-MOG group, even while the biological effect of rituximab on memory B-cell suppression was sustained.
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Neurofilament Light Correlates With Postoperative Delirium Severity
Measurement of postoperative plasma neurofilament light protein (NfL) in plasma appears to have a dose-dependent correlation with delirium severity, independent of inflammation. This observation provides evidence of neuronal injury from delirium.
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Status Epilepticus
Status epilepticus is a serious medical condition that is defined as a seizure lasting longer than five minutes or more than one seizure without recovery to baseline between seizures.
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Infectious Disease Alert Updates
Step-Wise Interventions for Hospital-Onset Clostridioides difficile
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Cefiderocol (Fetroja)
Cefiderocol is a novel siderophore cephalosporin with a wide spectrum of activity against difficult-to-treat gram-negative organisms for which there currently are limited treatment options.