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Hyperdynamic Left Ventricular Function: Good or Bad News?
A large population study has shown a U-shaped relationship between left ventricular ejection fraction (EF) and mortality, with a nadir at 60-65%. The authors identified a new group at high risk for death: those with an EF ≥ 70%.
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Osilodrostat Tablets (Isturisa)
Osilodrostat should be prescribed to adult patients with Cushing's disease for whom pituitary surgery is not an option or has not been curative.
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Cannabis in the Treatment of Headache and Migraine
The authors of this observational study found nearly a 50% reduction in self-reported headache and migraine severity following use of inhaled medicinal cannabis.
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Warfarin or DOACs for Atrial Fibrillation in Chronic Kidney Disease?
A large outpatient observational study of patients with atrial fibrillation and chronic kidney disease who were anticoagulated revealed that, compared to warfarin, direct oral anticoagulants exhibited less all-cause mortality and major bleeding with at least equivalent efficacy at preventing stroke.
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Anatomic vs. Functional Testing in Older Coronary Artery Disease Patients
An analysis of the PROMISE trial by age showed cardiovascular death or myocardial infarction was predicted by a positive stress test in patients with symptoms suggesting myocardial ischemia who were > age 65 years.
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Pharmacotherapy Considerations for COVID-19
A summary of selected pharmacotherapy options proposed to treat COVID-19.
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Beating the Pandemic: What Emergency Providers Should Know About COVID-19
The disease associated with the 2019 novel coronavirus (COVID-19) is now a significant event in world history, with uncertain but likely major consequences for individuals, families, healthcare workers, health systems, and the global economy. Although COVID-19 appears to pose only a limited danger to children, older adults face the possibility of much more serious manifestations. At this time it seems COVID-19 will demand the attention of most practitioners and allied health providers over the next year. Thus, familiarization with what is known so far about its pathophysiology, epidemiologic risk factors, treatment, and future directions for research is important as we face and fight this crisis united as healthcare providers.
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The Global COVID-19 Pandemic Was Predicted and Ignored
The human population explosion, international travel and migration, urbanization, and environmental exploitation set the stage for pandemics, and the trend likely will continue and intensify.
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Young Cancer Survivors at Increased Risk of Subsequent Endocrine Disease
A large Danish-based population cohort study documents that survivors of cancers arising in adolescence and young adulthood are at increased risk of subsequently developing a variety of endocrine disorders.
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Impact of Weight Loss on Lower Urinary Symptoms and Urinary Incontinence in Overweight and Obese Women
Weight loss interventions are associated with improvements in urinary incontinence in overweight and obese women at 1 to 2.9 years.