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Four Months of Rifampin Is Just as Effective, Safer, and Less Expensive than Nine Months of Isoniazid for Latent Tuberculosis
A health system cost comparison found that four months of rifampin was safer and less expensive than nine months of isoniazid in high-income countries, medium-income countries, and African countries.
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Antibiotic Use in COVID-19 Patients
Fifty-seven percent of patients with COVID-19 infection treated at 38 hospitals in Michigan received early empiric antibiotics, although only 3.5% of patients had documented community-onset bacterial co-infection.
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Seasonal Coronavirus: A “Common Cold Virus” that May Be Lethal in Severely Immunocompromised Patients
Seasonal coronaviruses, which are a frequent cause of benign upper respiratory tract infections, may be fatal in severely immunocompromised patients.
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Repeat SARS-CoV-2 Infection
Whole genome sequencing confirmed that repeat infection with SARS-CoV-2 is possible, something that has consequences for vaccine use and for public health.
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Considerations and Concerns with Vitamin C in Sepsis and Septic Shock
Sepsis remains a major healthcare problem associated with significant morbidity and mortality. Roles for hydrocortisone, ascorbic acid (vitamin C), and thiamine (HAT therapy) as potential adjuvants remain controversial.
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ORANGES and ACTS Trials: No Mortality Benefit with Ascorbic Acid, Thiamine, and Hydrocortisone in Septic Shock Patients
Two double-blinded, placebo-controlled, randomized trials involving 337 patients (ORANGES, n = 137; ACTS, n = 200) with sepsis and septic shock have shown that administration of ascorbic acid, thiamine, and hydrocortisone did not reduce organ dysfunction or improve overall mortality. However, both trials showed that this combination therapy was effective in reducing the time to achieve shock resolution or shock-free days.
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Sepsis Outcomes Improve, But Not at Minority-Serving Hospitals
ICU deaths declined 2% steadily annually at non-minority hospitals, according to a recent report. This was not true of minority-serving hospitals. Those hospitals also reported longer lengths of stay and more critical illness than non-minority hospitals.
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ICU Nurses Feel Marginalized During Ethical Conflicts
A pair of researchers analyzed open-ended responses from a survey with ICU nurses, and identified three themes.
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End-of-Life Experience Varies Depending on Geographical Region
Investigators were surprised by the striking degree to which the use of hospitalization and hospice varied across the United States, even among large metropolitan areas.
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Data Show Mistreatment of Medical Students Is Common
It is hard to say if the problem is worse, or if residents are just reporting it more. Regardless, this is a longstanding problem, but few effective solutions or prevention tactics have been implemented.