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Oral Calcitonin Gene-Related Peptide Antagonist for Prevention of Migraine
Atogepant, an oral calcitonin gene-related peptide (CGRP) antagonist, was shown to be effective and safe for migraine prevention. This adds an additional CGRP antagonist to the growing arsenal of such medications, both oral and parenteral, for both prevention and treatment of migraine.
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A Novel Therapy for Amyotrophic Lateral Sclerosis Shows Promise
A novel drug combination was taken from an animal model and tested in a Phase II trial of patients with amyotrophic lateral sclerosis. Although there was a trend toward benefit, there were no statistically significant endpoints at the end of the trial. Future trials need to enroll a larger number of patients.
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Transthyretin Amyloidosis and Neuropathy
Wild-type transthyretin amyloidosis, referred to as “senile” amyloidosis previously, usually occurs in the aging population and affects the peripheral nerves and the heart. Usually, neurological symptoms precede cardiac symptoms.
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CDC Backs Down on Testing Controversy
After widespread criticism from the medical community, the Centers for Disease Control and Prevention dropped a controversial recommendation that de-emphasized the importance of testing asymptomatic contacts of COVID-19 cases.
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Diagnosis and Treatment of Attention Deficit Hyperactivity Disorder
Presenting with persistent inattentiveness and/or hyperactivity and impulsivity severe enough to interfere with functioning, and occurring in more than one setting, attention deficit hyperactivity disorder is one of the most common neurodevelopmental disorders of childhood, with evidence of impairment often continuing into adult years.
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Vomiting and Diarrhea in Immunocompromised Patients
Patients who are immunosuppressed may exhibit subtle or atypical presentations of gastrointestinal infection, as well as complications of their underlying disease processes or treatments. Emergency physicians should maintain a high level of suspicion for life-threatening pathology and evaluate these patients using broad differentials.
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Infectious Disease Alert Updates
IL-6 Inhibition and Liver Failure; Can Chopsticks Make You Sick?
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Vitamin C, Thiamine, and Steroids for Septic Shock — Still Unproven
Combination treatment with ascorbic acid (vitamin C), thiamine (vitamin B1), and corticosteroids does not improve clinical outcomes in adults with septic shock.
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Biofilm, Tap Water, and a Nosocomial Mycobacterium abscessus Outbreak — Bring on the Sterile Water
Stopping a nosocomial Mycobacterium abscessus outbreak by eschewing tap water.
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Possible Aerosol Spread of SARS-CoV-2 in an Apartment Building
Although not definitive, evidence is consistent with aerosol spread of SARS-CoV-2 in an apartment building as a result of transport through the drainage system to apartments directly above.