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Remdesivir Injection (Veklury)
Remdesivir’s benefit appears to be modest, but may be better for those receiving low-flow oxygen.
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A Novel Rifabutin-Containing Combination Regimen Eradicates H. pylori Infection
Researchers found a significantly higher eradication rate for H. pylori with a 14-day regimen of rifabutin, amoxicillin, and omeprazole compared to 14 days of amoxicillin and omeprazole.
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Race Correction in Clinical Calculations: Is It Time to Reconsider?
Many clinical calculators use race as a predictive variable to assess risk for outcomes. Although most tools assume a genetic disposition for these outcomes, other factors, such as health disparities and other potential confounders, are more likely to be the underlying reasons for any race-related differences in outcomes.
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Perinatal Mental Health During the COVID-19 Pandemic: The Role of the OB/GYN
The obstetrical effect of COVID-19 has received attention worldwide. However, data examining the psychological effect on women in the perinatal period still are emerging. Although there is little doubt that COVID-19 has increased depression and anxiety in many demographic groups, a small amount of existing literature begins to give us some insight into the incidence, risk factors, and protective factors for mental illness in perinatal women during the COVID-19 pandemic.
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HPV Vaccination Reduces the Risk of Invasive Cervical Cancer
In this retrospective cohort study of women in Sweden, receipt of human papillomavirus vaccination prior to age 17 years was associated with an 88% decrease in cervical cancer, and vaccination at ages 17 to 30 years was associated with a 53% decrease in cervical cancer.
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Female Caregivers May Delay Seeking Care for Pelvic Floor Disorders
One-third of patients presenting for urogynecologic subspecialty care are caregivers. Of these, women caring for an adult are more likely to delay seeking care for pelvic floor disorders.
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Prophylactic PCI for Vulnerable Plaques
In this proof-of-concept trial, treatment of non-flow limiting vulnerable plaque by PCI with bioabsorbable stents resulted in no significant difference in lesion-related events compared with optimal medical therapy, but there was a trend toward less angina driven revascularization in the stented group.
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Does Epidural Analgesia for Labor and Delivery Pain Relief Cause Autism?
In this retrospective cohort study of 147,895 singleton births, epidural anesthesia was used in 74.2% of cases and the hazard ratio for the subsequent diagnosis of autism spectrum disorders was 1.37 (95% confidence interval, 1.23-1.53).
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Are Anti-Inflammatory Drugs Useful in Malignant Pericardial Effusion?
Researchers studied patients with malignant pericardial effusion treated with pericardiocentesis and then anti-inflammatory agents if signs of adhesions or constriction were observed in post-drainage echocardiograms. Compared to NSAIDs and steroids, the authors found colchicine administration for 60 days reduced the rate of subsequent all-cause mortality and recurrent pericardial effusion.
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Using Sacubitril/Valsartan to Treat Heart Failure with Preserved Ejection Fraction
An analysis of renal outcomes in the PARAGON-HF trial revealed sacubitril/valsartan slows progression of kidney disease in patients with heart failure with preserved ejection fraction compared to valsartan alone.