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Researchers and IRBs Reconsider Minimal Risk After Trial Results
A clinical trial that involved studying electronic health record alerts for acute kidney injury seemed to be minimal risk to both the researchers and the IRBs that approved it. However, when two hospitals involved in the study reported an increased mortality rate, the researchers and the IRBs reconsidered what is truly minimal risk in these types of studies.
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Study Shows Research Programs and IRBs Responded Quickly to the Pandemic
Human research protection programs and IRBs nationwide responded quickly and efficiently to changing processes and policies during the early months of the COVID-19 pandemic, according to the results of a recent study.
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Infectious Disease Alert Updates
Outcome of Coccidioidomycosis in the Pre-Antifungal Era; PET Imaging for Fever of Unknown Origin; High Rates of Thromboembolism in COVID-19
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Clinician Alert: XDR Salmonella Typhi Acquired in the United States
Nine patients in the United States with no travel history had typhoid fever due to extensively drug-resistant Salmonella Typhi.
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Ventricular Assist Device Infections: More Questions Than Answers?
Almost two-fifths of patients with left ventricular assist devices develop associated infections. The optimal appropriate management remains to be determined.
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Oral Moxifloxacin vs. Intravenous Ertapenem Followed by Oral Levofloxacin and Metronidazole for Acute Appendicitis
A randomized controlled clinical trial found that a seven-day course of oral moxifloxacin was not noninferior to two days of intravenous ertapenem followed by five days of levofloxacin and metronidazole in adults with uncomplicated acute appendicitis.
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Unexpected Pediatric Benefits of the COVID-19 Pandemic
Despite the global tragedy of the COVID-19 pandemic, clinical experience suggests that there also have been some favorable indirect effects of pandemic-induced lockdowns on pediatric health. Specifically, there are lower rates of unscheduled primary care visits, emergency department visits, and hospitalizations for medical problems – without an increase in incompletely managed serious diseases.
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Getting to the Super Bowl: Lessons from the NFL on Controlling COVID-19
Aggressive implementation of mitigation procedures with continual evaluations and adjustments allowed the National Football League to complete their season with minimal COVID-19 transmission.
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Virus, Variants, Vaccines
The emergence of SARS-CoV-2 variants may compromise the efficacy of current vaccines.
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Mindfulness in Disadvantaged Populations
Participation in mindfulness-based group therapy shows promise for reducing stress and improving functioning in this pilot study involving 27 socioeconomically disadvantaged African-American women.