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Mifepristone as an Adjunct to Misoprostol for Pregnancy Termination
In this prospective, double-blind, randomized, placebo-controlled trial, pretreatment with 200 mg of mifepristone 24 to 48 hours before labor induction using misoprostol significantly reduced time to delivery among demised fetuses between 14 and 28 weeks of gestation. Maternal complications were equivalent in both groups.
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Changes to Medication Abortion Could Result in Pharmacy Dispensing of the Drug
The easing of the risk evaluation and mitigation strategy restriction on mifepristone will make it easier for women to obtain the drug and could allow for pharmacy dispensing of the drug. Pharmacists should have a seat at the table in the conversation on dispensing prescription medication. -
Researchers Say It Is Time to Drop REMS Restriction on Mifepristone
The risk evaluation and mitigation strategy (REMS) restriction on mifepristone has been burdensome for providers and patients, researchers noted. The REMS restriction exacerbates the stigma around abortion care, which already disproportionately affects communities of color and young people. -
Disease-Specific Contraceptive Counseling Needed for Sickle Cell Disease Patients
Healthcare providers need to focus on educating women with sickle cell disease about different types of contraception, efficacy, and risks while addressing disease-specific concerns. Women with sickle cell disease are at risk for pregnancy complications, such as higher risks for maternal and fetal mortality, pre-eclampsia, and intrauterine growth restriction. -
Researchers Study COVID-19 Vaccine Outreach to Pregnant Women
The results of a recent study highlight the gaps in COVID-19 vaccination among pregnant women in the United States. Although pregnant women are at increased risk for severe illness and death from the disease, many remain unvaccinated. -
Reproductive Health Organizations Help Vaccinate Patients, Communities
Planned Parenthood and other reproductive health organizations have initiated COVID-19 vaccine outreach for their patients and communities. In addition to encouraging staff and patients to take the vaccine, the organizations have taken a positive COVID-19 vaccine message to minority communities and others hit hard by the pandemic. -
When in Doubt, Take It Out: Left Atrial Appendage Occlusion
In a randomized trial of patients with atrial fibrillation, left atrial appendage occlusion during elective cardiac surgery was associated with lower rates of ischemic stroke or systemic embolism after 30 days. -
Iron Therapy for Acute Heart Failure
Giving intravenous ferric carboxymaltose to stabilized post-acute heart failure patients with iron deficiency improved quality of life vs. placebo-treated patients within four weeks, which persisted during subsequent therapy for up to 24 weeks. -
Anticoagulation Plus Antiplatelet Therapy in Chronic Atherosclerosis
An analysis of the COMPASS trial for the secondary endpoint of mortality showed the combination of low-dose rivaroxaban and aspirin significantly lowered the all-cause mortality rate vs. low-dose aspirin alone. -
Important Lessons About Edge-to-Edge Repair
This analysis of mitral surgery after failed transcatheter edge-to-edge repair demonstrates high rates of valve replacement as opposed to repair. Surgical mortality was higher than predicted but was significantly lower in high-volume centers.