Clinical Cardiology Alert – December 1, 2016
December 1, 2016
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Spironolactone Improves Exercise Capacity in Diastolic Heart Failure
In a small randomized, controlled trial of patients presenting with heart failure with preserved ejection fraction, treatment with spironolactone was associated with improved exercise capacity and less exercise-induced increase in left ventricular filling pressures.
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Left Main Confusion: Two Randomized Trials Reach Seemingly Opposite Conclusions
The NOBLE and EXCEL trials randomized patients presenting with left main disease to treatment with percutaneous coronary intervention or coronary artery bypass graft.
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MitraClip Experience in Functional Mitral Regurgitation
A post-regulatory approval, observational study of patients with symptomatic functional mitral regurgitation stratified by baseline left ventricular ejection fraction (LVEF) showed that these patients received substantial benefit at low rates of hospital mortality and other adverse events, regardless of baseline LVEF.
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Diastolic Blood Pressure Goals
An analysis of the community-based ARIC study showed that low diastolic blood pressures were associated with higher baseline and subsequent troponin T levels and adverse cardiac events, but not stroke.
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Recently Diagnosed Idiopathic Dilated Cardiomyopathy Patients Are at Risk for Major Arrhythmic Events
Patients with recently diagnosed idiopathic dilated cardiomyopathy are at marked risk of major arrhythmia events that are neither well-predicted by traditional methods nor protected against by defibrillator implantation more than three months after diagnosis.