Pharmacology Watch – December 1, 2017
December 1, 2017
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Possible Link Between Acetaminophen Use During Pregnancy and Later ADHD Development
A recent study showed that long-term maternal use of acetaminophen during pregnancy was associated substantially with ADHD, even after adjusting for indications of use, familial risk of ADHD, and other potential confounders. However, given that paternal use of acetaminophen also was associated with ADHD, the causal role of acetaminophen can be questioned.
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Lowering Dementia Risk in Atrial Fibrillation Patients
Oral anticoagulants may reduce the risk of dementia in patients with atrial fibrillation, according to a new study from Sweden.
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Monitoring Bleeding Risks Associated With Non-vitamin K Oral Anticoagulants
In a recent trial, among patients taking non-vitamin K oral anticoagulants for atrial fibrillation, concurrent use of amiodarone, fluconazole, rifampin, and phenytoin was associated with increased risk of major bleeding.
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Rivaroxaban Plus Aspirin for Secondary Prevention
Among patients with stable cardiovascular disease, those assigned to rivaroxaban plus aspirin in a recent study experienced better cardiovascular outcomes and more major bleeding events than those assigned to aspirin alone. Rivaroxaban alone was no better than aspirin.
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FDA Actions
In this section: FDA approves new herpes zoster vaccine, greenlights second gene therapy for cancer, and issues warnings to companies marketing cannabidiol.