OB/GYN Clinical Alert – September 1, 2007
September 1, 2007
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SSRIs and Fractures
Richards and colleagues representing the Canadian Multicentre Osteoporosis Study Research Group reported the effect of daily selective serotonin reuptake inhibitors (SSRIs) use in a prospective cohort study in 7 regional centers of 5008 adults over the age of 50. -
Gemcitabine vs Pegylated Liposomal Doxorubicin in Patients with Platinum-resistant Ovarian Cancer
Ovarian cancer patients relapsing within 6 months of their primary therapy represent among the most challenging patients to treat. Generally, in this setting, most patients have only been exposed to one or two agents, yet they are phenotypically resistant to most chemotherapeutics, making drug discovery of paramount importance. -
Neonatal and Five Year Outcomes after Birth at 30-34 Weeks of Gestation
In the latest issue of Obstetrics and Gynecology there were 3 papers, loosely tied together, that should provide important guidance to clinicians dealing with preterm labor (PTL). One article will be the source for the primary review, but the others will be folded into the comments sections. -
Change in Breast Cancer Prevalence
Glass and colleagues from the Kaiser Permanente Northwest Center for Health Research compared breast cancer incidence rates with use of screening mammography and postmenopausal hormone therapy prescriptions between 1980 and 2006. -
Dietary Intake and Prognosis after Breast Cancer
Results of the Women's Healthy Eating and Living (WHEL) study were published in a recent issue of JAMA. In this multicenter, randomized controlled trial a total of 3088 women diagnosed with early-stage breast cancer (stage I-IIIa) within the previous four years were randomized to a diet rich in vegetables, fruit and fiber and low in fat, vs a regular diet. -
Pharmacology Watch: Oral Anticoagulant + Antiplatelet Therapy = Danger
High-Dose Statin Therapy, Value for Older Adults; Simvastatin, Best for Parkinson's Disease; Polyethylene Glycol for Chronic Constipation; FDA Actions -
Clinical Briefs in Primary Care supplement