OB/GYN Clinical Alert – October 1, 2009

October 1, 2009

• HPV Vaccine: When Too Old Is Still Quite Young

  Women aged 24-45 years with no history of genital warts or HPV-related cervical disease received either the quadrivalent HPV vaccine (n = 1911) or placebo vaccine (n = 1908) in a multicenter, international, parallel group, randomized, placebo-controlled, double-blind study.

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• Fertility-sparing Options for Ovarian Cancer Patients

  The standard surgical approach to ovarian cancer in medically fit patients is extirpation of the uterus, tubes, and ovaries, along with systematic staging or debulking of metastatic disease.

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• Hormone Therapy and Ovarian Cancer: Another Affirmation

  Previous studies have suggested that menopausal hormone therapy is associated with the risk of developing epithelial ovarian cancer. The strongest association comes from examining "ever use" against those never exposed.

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• Special Feature: Contemporary Management of Twins

  Prior to 1980, twins comprised about 1 in 40 pregnancies, but now, with assisted reproductive technology (ART) being widely used, the incidence of twins has risen to 1 in 20 pregnancies.

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• Pharmacology Watch: WHO Issues Global Alert on Antiviral Use

  In this issue: WHO recommendations for antiviral use for H1N1 flu; antibiotic use trends for acute respiratory tract infection; denosumab clears FDA Expert Panel; FDA Actions.

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• Clinical Briefs in Primary Care supplement

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