OB/GYN Clinical Alert – June 1, 2010

June 1, 2010

• Bone Density Recovery with DMPA

  Depot medroxyprogesterone acetate (DMPA) is a highly effective progestin-only contraceptive that is widely used by adolescents. DMPA is also associated with suppression of ovarian production of estradiol, and with a decrease in bone density in some users.

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• Making a Dent in Teen Pregnancy Rates

  This is a small U.S.-based clinical trial of 23 adolescent women (ages 14-18) randomized to levonorgestrel-releasing vs Copper T intrauterine device (IUD).

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• Sonographic Prediction of Fetal Macrosomia

  The management of a patient with suspected fetal macrosomia remains an enigma. Not being able to come up with a consistent plan of management for macrosomia is compounded by our inability to reliably predict it.

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• Special Feature: BRCA1/2 Mutations: Missed Opportunities

  The primary objective of this retrospective study was to estimate the incidence of genetic counseling referral for ovarian cancer patients who were at high risk for carrying a mutation in BRCA1 or BRCA2.

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• Pharmacology Watch: Atypical Fractures and Bisphosphonate Therapy

  In this issue: Fractures and bisphosphonate therapy, warfarin anticoagulation and influenza vaccine and cotrimoxazole, antiplatelet therapy with clopidogrel and aspirin, FDA Actions.

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• Clinical Briefs in Primary Care supplement

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