OB/GYN Clinical Alert – January 1, 2009

January 1, 2009

• The Impact of BRCA Mutation on Ovarian Cancer Treatment Outcomes

  Hereditary ovarian cancer syndromes are uncommon, but are most often represented by mutation in BRCA1/2.

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• Testosterone for Low Libido

  Davis and colleagues report the results of a one-year, randomized, controlled clinical trial of 814 women not on estrogen therapy from 65 centers in the United States, Canada, Australia, the United Kingdom, and Sweden with hypoactive sexual desire disorder treated with transdermal testosterone, 150 or 300 µg per day, or placebo.

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• Role of Hysteroscopy in Evaluating Chronic Pelvic Pain

  The authors present a series of gynecological conditions that are effectively diagnosed by hysteroscopy, including adenomyosis, chronic endometritis, Mullerian anomalies, retained fetal bones, endocervical ossification, and intrauterine abnormalities. In addition, they note that hysteroscopy can be a major part of the treatment for these conditions.

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• Special Feature: The Bioidentical Hormone Conflict

  The adverse publicity following publications from the Women's Health Initiative was a multibillion dollar bonanza for compounding pharmacies providing postmenopausal hormones.

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• Pharmacology Watch: JUPITER: C-reactive Protein a Marker for CV Events?

  In this issue: The JUPITER trial causes a stir; ACP practice guideline for antidepressant use; testosterone for low libido; continued shortage of Hib vaccine; FDA Actions.

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• Clinical Briefs in Primary Care supplement

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