OB/GYN Clinical Alert – August 1, 2008
August 1, 2008
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Postmenopausal Hormone Therapy and Stroke
The Nurses' Health Study reported an update of its data on the use of hormone therapy and stroke, focusing on the timing of initiation of treatment and the effect of estrogen doses. -
A New Standard for Uterine Leiomyosarcoma
Doxorubicin-based chemotherapy has remained a standard for the treatment of soft tissue sarcoma for decades. Recently, combination gemcitabine and docetaxel demonstrated significant clinical activity in a single-institution mixed population study of women with uterine leiomyosarcoma. -
Defining Interstitial Cystitis Based on Symptoms
The authors hypothesized that certain pain symptoms characterize IC/PBS. They reviewed criteria used in two recent studies to look for commonalities. -
Sweeping Membranes — Any Drawbacks?
It has been common practice to "strip" or "sweep" membranes after 38 weeks to initiate spontaneous labor or, at least, to discourage patients from delivering after 42 weeks. -
Mammography Combined with Ultrasound
Berg and colleagues from 21 centers in the U.S. report the results of a prospective, multicenter, randomized trial designed to validate the performance of screening ultrasound in conjunction with mammography in women with dense breasts and at high risk for breast cancer. -
Special Feature: Overview of The Fetal Origins of Adult Disease and The Role of The Obstetrician-Gynecologist in Predictive Health
The two main modifiers of pathogenesis are age and sex. Reversible and irreversible modifications to cellular machinery through genetic and epigenetic mechanisms begin with embryogenesis. For instance, certain aspects of in vitro culture conditions "imprint" genetically normal embryos by altering methylation patterns and gene expression. -
Pharmacology Watch: Bird Flu Vaccine Looks Promising
In This Issue: Baxter Bioscience has developed a whole-virus, two dose vaccine against avian flu; warning label now on antipsychotics regarding an increased risk of mortality in elderly patients treated for dementia-related psychosis; vitamin D for men with heart disease on horizon? A new oral anticoagulant may soon be available for prevention of thrombotic complications of hip or knee surgery; FDA Actions -
Clinical Briefs in Primary Care supplement