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Preimplantation Genetic Screening Improves IVF Success in Women with Diminished Ovarian Reserve

Low levels of anti-Müllerian hormone in combination with an elevated day 2-3 follicle-stimulating hormone is associated with a high rate of aneuploid embryos.

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Placenta Previa

A new study shows that the vast majority of low-lying placentas or marginal previas noted in second trimester patients resolved by term. However, there was a doubling of the rate of postpartum hemorrhage in these patients even if the placentas had migrated away from the cervix.

LNG-IUS and Nuisance Bleeding

In this randomized, controlled trial, tranexamic acid and mefanamic acid were no better than placebo in reducing the number of bleeding or spotting days in the first 3 months after LNG-IUS placement.

Targeted Therapy for LGSOC Shows Promise

Selumetinib, a selective MEK1/2 inhibitor, achieved objective responses in 15% of patients with recurrent low-grade serous ovarian cancer (LGSOC). The data are relevant as this uncommon tumor type is associated with general chemoresistance, frequent aberration in the MAPK pathway, and prolonged overall survival compared with its more common high-grade variant. Phase 3 trials are planned.

DRSP and Thrombosis: Do Gathering Clouds Imply a Storm or Poor Visability?

A review of incident cases of venous thrombosis in women using oral contraceptives (OCs) in a U.S. insurance database found that use of drospirenone-containing OCs containing 20 ìg of ethinyl estradiol (EE) was associated with a two-fold increase in risk compared to levonorgestrel pills. This risk was not increased with use of 30 ìg EE drospirenone pills.

Pharmacology Watch: Is Naproxen the Safest NSAID for the Heart?

NSAIDs and cardiovascular risk; new antithrombotic guidelines; warfarin during surgery; Pfizer selling Viagra online; azithromycin and cardiovascular risk; and FDA actions.

Clinical Briefs in Primary Care Supplement

OB/GYN Clinical Alert – July 1, 2013

July 1, 2013