OB/GYN Clinical Alert – January 1, 2015

January 1, 2015

• Use of Letrozole vs Clomiphene Citrate for Ovulation Induction in Women with PCOS

  Polycystic ovarian syndrome patients with normospermic partners undergoing ovulation induction with letrozole had a higher live birth rate and no increase in adverse outcomes than women who received clomiphene citrate.

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• Fibroids and Pregnancy

  A recent study in patients with fibroids has correlated the size, location, and number of fibroids with the rate of preterm birth, postpartum hemorrhage, need for cesarean section, and fetal size findings that can be useful in counseling patients with fibroids.

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• What Is the Best Oral Contraceptive Regimen for Obese Women?

  According to this pharmacokinetic study, the cyclic use of 20 mcg ethinyl estradiol oral contraceptives is problematic for obese women. Ovarian activity was better suppressed with continuous use (omitting the hormone-free interval) of the same dose oral contraceptive or increasing to a higher dose 30 mcg ethinyl estradiol oral contraceptive

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• Talcum Powder the ‘Pluto’ of Prognostic Factors for Ovarian Cancer

  A large prospective cohort study of perineal talc use demonstrated no increased risk of ovarian cancer overall or within any histological subtype. In addition, no association with talc application method was observed.

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