OB/GYN Clinical Alert – August 1, 2004

August 1, 2004

• The WHI and Cognition

  The womens health initiative reported their results on cognition and dementia combining the canceled estrogen-only arm with the canceled estrogen-progestin arm of the randomized trial; the data are derived from an ancillary study of the trial entitled The Womens Health Initiative Memory Study (WHIMS).

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• Vasa Previa: The Effect of Prenatal Diagnosis on Outcomes

  Good outcomes with vasa previa depend primarily on prenatal diagnosis and cesarean delivery at 35 weeks of gestation or earlier should rupture of membranes, labor, or significant bleeding occur.

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• Prediction of Optimal vs Suboptimal Cytoreduction of Advanced-Stage Serous Ovarian Cancer with the Use of Microarrays

  These data support the hypothesis that favorable survival that is associated with optimal debulking of advanced ovarian cancers is due to, at least in part, the underlying biologic characteristics of these cancers.

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• Special Feature: Postmenopausal Hormone Therapy and the Risk of Ovarian Cancer

  The canceled estrogen-progestin arm of the Womens Health Initiative reported an increase in ovarian cancer that was not statistically significant, prompting the authors to say: The possibility of an increased risk of ovarian cancer incidence and mortality remains worrisome and needs confirmation.

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• Pharmacology Watch: The Importance of Publishing Negative Clinical Studies

  Cognitive Effects of Estrogen Therapy; Vitamin Therapy and Restenosis; Echinacea and the Common Cold; Effects of Paxil in Children Under 18; FDA Actions.

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• Clinical Briefs in Primary Care supplement

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