OB/GYN Clinical Alert
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Individualizing Opioid Prescriptions After Cesarean Delivery
A multicenter, randomized controlled trial of 5,521 participants who underwent uncomplicated cesarean deliveries found that an individualized opioid prescription protocol (IOPP) with shared decision-making was noninferior to a fixed prescription regarding the proportion of participants experiencing moderate to severe pain one week post-discharge, while significantly reducing the number of opioid tablets prescribed at discharge (median of 14 tablets vs. 20 tablets, P < 0.001).
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Twelve-Month Contraceptive Prescriptions: Do They Make a Difference?
In this national retrospective cohort study of patients on Medicaid, states with 12-month hormonal contraceptive supply policies increased their 12-month dispensing by only 4.39% compared to the pre-policy period. The majority of this increase was contributed by the state of California.
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Adverse Outcome Predictors in Pregnancies Complicated by SLE
A prior history of lupus nephritis, active systemic lupus erythematosus (SLE) at conception, secondary antiphospholipid syndrome, and chronic hypertension are critical predictors of adverse pregnancy outcomes in women with SLE.
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Endometrial Cancer: An Update to Classification Using Molecular Features
The classification of endometrial cancer is evolving, transitioning from histological subtypes to molecular profiling. Four key molecular subtypes (POLE ultramutated, MSI unstable, p53 mutant, and NSMP) guide prognosis and treatment. The integration of molecular features into staging highlights their clinical relevance for improving diagnostic accuracy and therapeutic strategies.