Neurology Alert – March 1, 2017
March 1, 2017
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New Tools for the Diagnosis of CJD
Cerebrospinal fluid analysis using second-generation, real-time, quaking-induced conversion has a high sensitivity and specificity for the diagnosis of Creutzfeldt-Jakob disease.
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Ocrelizumab for Multiple Sclerosis
A Phase III trial of ocrelizumab in primary-progressive multiple sclerosis and two Phase III trials of ocrelizumab in relapsing-remitting multiple sclerosis have demonstrated efficacy with treatment.
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Differences in Disease Duration in LBD May Be Related to Pathologic Burden
This observational study of 807 autopsy-confirmed cases of Lewy body disease used Braak neurofibrillary tangle staging, frequency of neuritic plaques, and Lewy body staging to demonstrate that those individuals who had diffuse LBD had a shorter disease duration than those with transitional LBD localized to the limbic region.
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Guillain-Barré Syndrome and Hepatitis E
Hepatitis E is the most common form of viral hepatitis worldwide and often is asymptomatic. But it is commonly associated with Guillain-Barré syndrome and Guillain-Barré variants.
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EEG Reactivity Testing in Comatose Patients After Severe Brain Injury
Studies assessing EEG reactivity in comatose patients after severe brain injuries are highly variable and almost never provide replicable definitions for presence or absence of EEG reactivity, even though it is used increasingly as a prognostic measure.
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First-ever Study of Genome Sequencing in the Common Forms of Epilepsy
In the first study with genome sequencing in the common forms of epilepsy, ultra-rare genetic mutations of known epilepsy genes were over-represented in the epilepsy population, compared to controls.