Neurology Alert – May 1, 2016
May 1, 2016
View Issues
-
Clinical Characterization of Inherited Erythromelalgia Due to Sodium Channel Mutations
A detailed non-interventional clinical study of patients with inherited erythromelalgia who carry gain-of-function mutations of voltage-gated sodium channel Nav1.7 further characterized pain phenotypes in this disorder and showed wide variability of pain symptoms.
-
Relationship Between Spikes and Seizures Using an Implantable Intracranial Detection Device
The authors report the preliminary findings for an implantable ambulatory intracranial recording device for seizure detection in 15 subjects. One of the primary findings was that spike rate significantly changed prior to seizures in nine of 15 subjects. Six of these subjects showed a significant decrease in spiking prior to ictal onset, whereas the remaining three showed a significant increase in spiking and these three subjects had the best seizure prediction results.
-
Carpal Tunnel Syndrome: Everything You Want To Know, and More
Carpal tunnel syndrome can be reliably diagnosed, only with nerve conduction studies, and this test should be performed before any invasive treatments are initiated.
-
Differentiating Sarcoidosis from Neuromyelitis Optic in Patients with Transverse Myelitis
Based on a retrospective analysis of 71 patients with an neuromyelitis optica spectrum disorder (n = 37) or sarcoidosis (n = 34), whose initial presentation was longitudinally extensive transverse myelitis (≥ 3 vertebral segments), the authors report clinical, radiologic, and laboratory findings that help distinguish one from the other.
-
Leigh Syndrome: Insights and Implications from Advances in Next-generation Sequencing
Leigh syndrome is a genetically heterogeneous neurodevelopmental disorder. The application of next-generation sequencing has enabled a deeper understanding of the diverse nature of the genetic and molecular etiologies that give rise to the shared clinical phenotype of Leigh syndrome.