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Genetic vs Environmental Factors in the Causation of Alzheimer’s Disease

The availability of comprehensive records of public health in Scandinavian countries is a major advantage in working out epidemiological studies. The present study of Swedish twins including many older than 80 now suggests that the genetic component of AD may be less than previously thought.

Melatonin Fails to Improve Sleep in Alzheimer’s Disease

There are considerable anecdotal data suggesting that melatonin may improve sleep. Singer and colleagues carried out a trial of 2 sustained-release doses of melatoninone moderately high dose of 10 mg and one moderately low dose of 2.5 mg.

Improved Cortical Metabolism in Huntington’s Disease Patients Following Striatal Neural Grafting

The prospects for therapy in Huntingtons disease are rapidly improving. Another potential treatment is to use striatal neural grafts.

Alzheimer Metal Chelator Shows Some Promise in Phase II

Relying on careful monitoring to reduce the risk of toxicity, Ritchie and colleagues carried out a 36-week phase II test of the efficacy of clioquinol in reducing plasma beta-amyloid levels and slowing cognitive decline in patients with moderately severe Alzheimer's disease.

Subthalamic Stimulation and Urinary Function

In this elegant study, Seif and colleagues asked a simple question: does DBS alter urodynamic parameters in patients with Parkinson's disease?

Back to Basics: The Right Anti-Epileptic Drug for the Right Diagnosis

Benbadis and associates reviewed the medication history of patients with EEG-confirmed idiopathic generalized epilepsy.

Hepatitis C and Neuropathy

Fifty-one consecutive hepatitis c patients with neuropathy were evaluated to determine whether, and by what mechanism, cryoglobulinemia was associated with peripheral neuropathy.

Lamotrigine for Sciatica

Fourteen consecutive patients with sciatica were enrolled in this open-label trial of lamotrigine to determine its efficacy in pain control and its dose response curve.

ED Standards For Assessment of Cervical Spine Injury Compared

Stiell and associates, convinced that the National Emergency X-Radiology Utilization Study Low-Risk Criteria rule leads to unnecessary testing and delayed triage of patients in the ED, developed the Canadian C-Spine Rule to assess alert, stable patients for traumatic cervical spine injury.

Pharmacology Watch: Valacyclovir Reduces Genital Herpes Transmission

A once-a-day dose of a valacyclovir reduces the rate of transmission of genital herpes (HSV-2) from an infected partner to an uninfected susceptible partner, according to a new study.

Clinical Briefs in Primary Care Supplement

Neurology Alert – February 1, 2004

February 1, 2004