Neurology Alert – September 1, 2011
September 1, 2011
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Can We Identify Pre-Motor Parkinson's Disease in LRRK2 Carriers?
Evaluation of non-Parkinsonian carriers of the LRRK2 mutation associated with Parkinson's disease supports a model of pre-motor symptomatology, including impaired color discrimination and constipation, that could be related to pathology developing prior to that in the substantia nigra. -
Myopathic Side Effects from Statin Use
Symptoms of muscle pain and discomfort are common with statin use, but weakness and creatine kinase elevation are unusual. -
Does Higher Vitamin D Intake During Pregnancy Reduce the Risk of Multiple Sclerosis in Offspring?
Based on data from the Nurses' Health Study II, the authors report that higher maternal intake of vitamin D during pregnancy may be associated with a lower risk of multiple sclerosis in their children. -
Gabapentin Enacarbil for Sleep Disturbance in Restless Legs Syndrome
Gabapentin enacarbil is effective for sleep disturbance in moderate-to-severe primary restless legs syndrome, but frequently causes sleepiness and dizzinesss. -
A Newly Described Motor Neuron Disease Mimic
A new autosomal-dominant genetic disorder is described that has similarities to sporadic motor neuron disease. -
Stroke Alert: A Review of Current Clinical Stroke Literature
The incidence of stroke associated with pregnancy, especially cerebral venous sinus thrombosis, is increasing, with hypertension as a major culprit. Hypertension as a complication of pregnancy increases a woman's risk of stroke in the future. -
Clinical Briefs in Primary Care Supplement
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Pharmacology Watch
ACEI/ARB therapy for AS; safety alert issued for dronedarone; statins and cancer risk; nesiritide and heart failure; and FDA actions.