Neurology Alert – September 1, 2011

September 1, 2011

• Can We Identify Pre-Motor Parkinson's Disease in LRRK2 Carriers?

  Evaluation of non-Parkinsonian carriers of the LRRK2 mutation associated with Parkinson's disease supports a model of pre-motor symptomatology, including impaired color discrimination and constipation, that could be related to pathology developing prior to that in the substantia nigra.

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• Myopathic Side Effects from Statin Use

  Symptoms of muscle pain and discomfort are common with statin use, but weakness and creatine kinase elevation are unusual.

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• Does Higher Vitamin D Intake During Pregnancy Reduce the Risk of Multiple Sclerosis in Offspring?

  Based on data from the Nurses' Health Study II, the authors report that higher maternal intake of vitamin D during pregnancy may be associated with a lower risk of multiple sclerosis in their children.

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• Gabapentin Enacarbil for Sleep Disturbance in Restless Legs Syndrome

  Gabapentin enacarbil is effective for sleep disturbance in moderate-to-severe primary restless legs syndrome, but frequently causes sleepiness and dizzinesss.

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• A Newly Described Motor Neuron Disease Mimic

  A new autosomal-dominant genetic disorder is described that has similarities to sporadic motor neuron disease.

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• Stroke Alert: A Review of Current Clinical Stroke Literature

  The incidence of stroke associated with pregnancy, especially cerebral venous sinus thrombosis, is increasing, with hypertension as a major culprit. Hypertension as a complication of pregnancy increases a woman's risk of stroke in the future.

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• Clinical Briefs in Primary Care Supplement

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• Pharmacology Watch

  ACEI/ARB therapy for AS; safety alert issued for dronedarone; statins and cancer risk; nesiritide and heart failure; and FDA actions.

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