Neurology Alert – March 1, 2012
March 1, 2012
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Sodium Channel Mutations in Idiopathic Small Fiber Neuropathy
Small fiber neuropathy (SFN) is a relatively common disorder that affects small somatic and/or autonomic nerves. Known causes include diabetes, vitamin B12 deficiency, and Sjogren's syndrome among others, although the condition is idiopathic in most cases. -
Sensory Neuronopathy in Patients with Recessive Polymerase γ Mutations
Detailed neuropathological investigation of patients with sensory neuronopathy and polymerase γ mutations revealed evidence of posterior column atrophy in spinal cord sections and marked neuronal cell loss with severe mitochondrial biochemical abnormalities (involving respiratory chain complexes I and IV) in the dorsal root ganglia. -
Electromyography in Anticoagulated Patients
Needle EMG is safe in patients who are taking therapeutic doses of antiplatelet or anticoagulant medications. -
The Specificity of Anti- aquaporin-4 Antibodies for Neuromyelitis Optica Is Further Validated
This study validated that anti-aquaporin-4 antibodies are highly specific (99.8%) for Devic's disease and related disorders when tested in a large series of miscellaneous autoimmune and non-autoimmune systemic diseases. -
Cognitive, Motor, and Brain Volume Deficits in Children with Growth Hormone Deficiency
Children with isolated growth hormone deficiency have lower IQ, worse motor skills, and several brain regions with smaller volumes than carefully selected controls. -
Stroke Alert: A Review of Current Clinical Stroke Literature
Of all ischemic stroke patients treated with iv al- teplase (tPA), only about half will achieve recanalization and have a good outcome (mRS 0 to 2). -
Clinical Briefs in Primary Care Supplement
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Pharmacology Watch
New treatment for prostate cancer; avastin and breast cancer; new CMS disclosure rule; and FDA actions.