Neurology Alert – July 1, 2010

July 1, 2010

• Neurology of Sjögren's Syndrome

  Peripheral and central nervous system involvement is common in Sjögren's syndrome, and may mimic multiple sclerosis or neuromyelitis optica.

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• Monoclonal Gammopathy and the CNS

  Nine of nineteen patients with monoclonal gammopathy, referred for evaluation of peripheral neuropathy, were found to have one or more clinical signs of CNS involvement.

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• Statins Do Not Appear to Slow the Progression of Alzheimer's Disease

  In this large, well-powered, prospective, randomized trial, treatment of Alzheimer's patients with a high-dose statin did not have a significant effect on cognitive decline.

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• Multiple Sclerosis: The Eyes Have It

  Pathological study shows atrophy within the inner nuclear layer of the retina and uveal tract inflammation in eyes from patients with multiple sclerosis

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• Medical Therapy Alone vs Addition of Deep Brain Stimulation in Advanced PD

  Deep brain stimulation (DBS) is an effective treatment in Parkinson's disease with motor fluctuations and dyskinesias. However, given the potential adverse events, proper patient selection is vital.

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• Stroke Alert: A Review of Current Clinical Stroke Literature

  Atherosclerotic plaques in the aortic arch are considered to be a potential source of embolism to the brain and a cause of some ischemic strokes, but the role of complex plaques (> 4 mm thickness, ulcerated, superimposed thrombi) in the proximal descending aorta (DAo) is uncertain.

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• Clinical Briefs in Primary Care Supplement

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• Pharmacology Watch

  New reports about proton pump inhibitors and the effects of gastric suppression, pioglitazone vs vitamin E for non-alcoholic steatohepatitis, metformin and vitamin B12 deficiency, and FDA Actions.

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