Neurology Alert – June 1, 2013

June 1, 2013

• Cognitive Dysfunction and Depression in Retired NFL Players

  In former, aging, National Football League players, fluid-attenuated inversion recovery scans showed increased total and deep white matter hyperintensity volumes, while diffusion tensor imaging showed decreased fractional anisotropy reflecting white matter disruption, and this is associated with cognitive impairments and depression.

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• Should We Use Combination Therapy for Multiple Sclerosis?

  The combination of interferon beta 1a (30 mcg IM weekly) and glatiramer acetate was not more effective on annualized relapse rate in multiple sclerosis compared to either treatment alone.

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• Are There Interactions Between Vascular Brain Disease, Amyloid Deposition, and Dementia?

  In a study of the elderly who are normal or have mild cognitive impairment, vascular brain disease and brain amyloid deposition appear to be independent risks for dementia.

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• Stroke Alert: A Review of Current Clinical Stroke Literature

  Which Patients Taking Warfarin for Atrial Fibrillation Have an Ongoing Risk for Stroke?; Who Gets Chronic Pain After a Stroke?; Clinical Features and Outcome of Basilar Artery Occlusion

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• Acute Seizures and Epilepsy Risk in Pediatric Intracerebral Hemorrhage

  Children with intracerebral hemorrhage are at increased risk for seizures and epilepsy compared to adults, particularly those who develop elevated intracranial pressures.

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• Nocturnal Leg Cramps

  Nocturnal calf cramps are usually benign and respond to stretching and muscle-strengthening exercises.

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• Pharmacology Watch: Do Perioperative Beta-Blockers Reduce Mortality?

  Beta-blockers and noncardiac surgery; prenatal medication exposure and risk of autism; reasons for statin discontinuations; and FDA actions.

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• Clinical Briefs in Primary Care Supplement

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