Neurology Alert – January 1, 2014

January 1, 2014

• Wernicke-Korsakoff Syndrome: Diagnosis and Pathogenesis

  Wernicke-Korsakoff syndrome, consisting of the triad of mental status changes, ocular motility abnormalities, and ataxia, in the setting of thiamine deficiency, remains a clinical diagnosis.

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• Hyperkalemic Periodic Paralysis

  Hyperkalemic periodic paralysis has now been well characterized clinically, physiologically, and genetically.

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• Iatrogenic Fungal Meningitis: Lessons Learned?

  An outbreak of fungal meningitis and paraspinal infections occurred over the past year due to contaminated methylprednisolone injections.

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• Optic Disc Cupping and Cognitive Decline: Three-year Prospective Study Demonstrates Association

  This long-term epidemiological study shows an association between glaucoma and Alzheimer's disease.

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• Brain Volume Abnormalities in Lesch-Nyhan Disease

  Subjects with Lesch-Nyhan disease and Lesch-Nyhan variant have significant reductions in brain size in the basal ganglia as well as several cortical areas.

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