Neurology Alert – February 1, 2005

February 1, 2005

• Is Vitamin E Useful For the Prevention or Treatment of Amyotrophic Lateral Sclerosis?

  Vitamin E had no significant effects in slowing disease progression, and no significant side effects in the patient population were encountered. Patients who regularly take vitamin E have a 60% reduced risk of getting ALS.

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• Acute Stroke Therapy Beyond IV tPA: Clot Removal — Bust It Up or Pull It Out

  This phase 1 study shows that cerebral embolectomy with the Merci Retriever was safe and that successful recanalization could benefit a significant number of patients, even when performed in an extended 8-hour time window.

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• Back to Basics: The EEG in CJD

  These data prove the high diagnostic value of our objective EEG criteria in CJD.

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• Challenges in Parkinson’s Disease Dementia Treatment

  In this placebo-controlled study, rivastigmine was associated with moderate improvements in dementia associated with Parkinsons disease but also with higher rates of nausea, vomiting, and tremor.

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• Diabetic Autonomic Neuropathy

  These findings indicate that autonomic symptoms and deficits are common in diabetes, but mild in severity, and that the correlation between symptom scores and deficits is overall weak in mild diabetic neuropathy, emphasizing the need to separately evaluate autonomic symptoms.

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• Amyloid Neuropathy

  If routine staining is negative for amyloid, Congo red and thioflavine S staining need be performed, with ultrastructural examination of Epon-embedded nerve. Anti-light-chain and transthyretin immunostaining of frozen nerve completes the investigation.

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• Clinical Briefs in Primary Care Supplement

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• Pharmacology Watch: Statins and the Incidence of Rhabdomyolysis

  The most commonly prescribed statins have a low incidence of rhabdomyolysis, according to the results a new study of more than 250,000 patients.

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