Neurology Alert – November 1, 2005
November 1, 2005
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Clinical Briefs in Primary Care supplement
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Pharmacology Watch
Roche is Under Pressure Over Its Antiviral Drug Tamiflu; ACE Inhibitors or ARBs for Prediabetics?; Xigris is Approved for Severe Sepsis; ACE Inhibitors Inhibiting Aortic Valve Stenosis?; FDA Actions -
Carotid and Vertebral Dissection — Is Anticoagulation Justified?
There is a role for endovascular therapy, such as stenting, as reported in Stroke, in the setting of failed medical management with anticoagulants. -
Review: Peripheral Nerves and Paraneoplasia
Whole body fluorodeoxyglucose positron emission tomography scanning helps uncover the associated tumor, and recently proposed criteria may assist in the diagnosis. In many instances, prompt treatment of the tumor and immunotherapy result in symptom stabilization or neurologic improvement. -
The FOUR Score vs the Glasgow Coma Scale
The probability of in-hospital death was higher for patients with the lowest total FOUR score than for those with the lowest total GCS score. -
Treatment of Low-Grade Gliomas — Watch and Wait or Give Post-Operative Radiation Immediately?
In a randomized trial comparing immediate radiation therapy to delayed treatment in patients who underwent primary surgical resection of low-grade gliomas, overall survival was not significantly different between the 2 groups. -
Deep Brain Stimulation (DBS) Is a safe and Effective Treatment for Medically Refractory Essential Tremor
In a consecutive case series of 18 patients with severe essential tremor who underwent implantation of bilateral thalamic DBS electrodes, high-frequency stimulation resulted in significant, long-term improvement in their quality of life. -
Frontotemporal Dementias: A Clinicopathologic Approach To a Heterogeneous Syndrome
Although the tau negative and positive histologies are predicted to some extent by the clinical onset, the extent of the overlap and the convergence of the syndromes in the course of the disease argue in favor of maintaining the clinical and pathological varieties under a single umbrella.