– May 1, 2004
May 1, 2004
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The Value of Post Adjuvant Chemotherapy Screening in Colorectal Cancer Patients
In an analysis of important clinical outcomes after adjuvant chemotherapy for stage II and III colorectal cancer, Chau and colleagues from the United Kingdom reviewed the experiences of 530 patients. Of these, 154 relapsed with metastatic disease, local recurrence, or metachronous tumor. -
Restaging Surgery for Women with Borderline Ovarian Tumors: Results of a French Mulitcenter Study
Women who initially were diagnosed with Stage IA disease and who had serous borderline tumors or underwent cystectomy appeared to derive the most benefit from restaging surgery. Nonetheless, the indications for restaging surgery remain controversial, as no difference in recurrence rate was observed between women who underwent restaging and those who did not. -
Phase II Data on Cetuximab (Erbitux)
In a phase II trial of cetuximab (Erbitux) given once weekly to patients with advanced colorectal cancer who had failed prior irinotecan treatment, a modest response rate was observed and the toxicity profile was shown to be manageable. -
High-Dose Imatinib Mesylate (Gleevec®) for CML
Imatinib was administered to newly diagnosed patients with chronic-phase myelogenous leukemia at a dose (800 mg daily) double what is commonly prescribed. Cytogenetic and molecular responses were significantly better than observed in an historical cohort of similar patients treated with 400 mg daily. -
BRCA Germline Mutations in Jewish Women with Uterine Serous Papillary Carcinoma
The loss of heterozygosity in the tumor tissue of carriers coupled with the high frequency of patient and family history of breast and ovarian malignancies suggest that USPC might be part of the manifestation of familial breast-ovarian cancer in Ashkenazi Jews. -
Pharmacology Watch: Atherosclerosis Reversed With Lipid-Lowering Drugs
Positive Alendronate Data in Osteoporosis; NSAIDs For Myocardial Infarction; Four-Hour Window for CAP Patients; FDA Actions. -
Clinical Briefs in Primary Care Supplement