– February 1, 2010
February 1, 2010
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Detection and Significance of Circulating Tumor Cells in Patients with Metastatic Breast Cancer
In this review of 195 patients with metastatic breast cancer, detection of 5 or more circulating cancer cells in 7.5 mL of whole blood correlated with reduced overall survival. Furthermore, the presence of extensive bone metastases, as detected by PET/CT, was shown to be associated with increased circulating tumor cells (CTC). -
Illustrative Case Series: Colon Cancer in a Piano Instructor
A 68-year-old white female presented to her internist complaining of fatigue for the past month. The patient is a piano teacher who traveled to her students' houses for their lessons, which had become a significant effort for her. -
Combination Oral Chemotherapy for Second-line SCLC
In a retrospective review of 71 patients treated in either a second- or third-line setting for small-cell lung cancer (SCLC) at a single institution, three orally administered drugs (lomustine, etoposide, and cyclophosphamide) were shown to be effective in producing responses (overall response rate 38%) but had little effect on overall survival (median survival 19 weeks). -
Lymphoma/Leukemia Risk among Morticians
Among funeral workers, the duration of embalming practice and related formaldehyde exposure were significantly associated with an increased risk for mortality from myeloid leukemia. -
Clinical Briefs in Primary Care Supplement
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Pharmacology Watch
Results from a Phase 3 study of dabigatran, intensive lipid-lowering in CVD, H1N1 vaccine dosing and efficacy, and FDA Actions