– July 1, 2005
July 1, 2005
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Acute Leukemia in Polycythemia Vera
Factors associated with leukemia development in patients with polycythemia vera were examined in a cohort of 1638 patients enrolled in an observational study. Older age, alkylating agent treatment and female gender were demonstrated to be significant risks, hydroxyurea treatment was not. -
Irinotecan or Oxaliplatin Combined with Leucovorin and 5-Fluorouracil
The IRI/LV/5-FU and OXA/LV/5-FU regimens demonstrated equally substantial efficacies and manageable toxicity profiles in the first-line treatment of patients with advanced CRC. However, IRI/LV/5-FU may be the preferable regimen to avoid significant neurotoxicity associated with OXA/LV/5-FU. -
Late Mortality After Autologous Transplantation
Survivors 2 years or more after autologous stem cell transplant for AML, ALL, NHL, and HD remain at significant risk of death, with 29% mortality, almost entirely between 2 and 10 years after transplant. While 56% died of relapse of the primary disease, 43% died from treatment related complications, many of whom suffered from therapy related MDS or AML. -
Breast Cancer in Young Women: The M.D. Anderson Experience
Breast cancer in young women is uncommon, but when it does occur, it is thought to be very aggressive. In this large series of young (< 35 years old) patients from a single institution seen over a 13-year period, high tumor grade, hormone receptor negativity, and family history of ovarian cancer turned out to be significant negative prognostic indicators. -
Association Between Hydration Volume and Symptoms in Terminally Ill Cancer Patients with Abdominal Malignancies
Artificial hydration therapy could alleviate membranous dehydration signs, but could worsen peripheral edema, ascites, and pleural effusions. It is suggested that the potential benefits of artificial hydration therapy should be balanced with the risk of worsening fluid retention symptoms. -
Pharmacology Watch: Rifamixin for the Prevention of Traveler’s Diarrhea?
Erectile Dysfunction and Visual Disturbance; Mixed News on Statins; FDA Actions. -
Clinical Briefs in Primary Care Supplement