– February 1, 2003
February 1, 2003
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Transperineal Interstitial Photodynamic Therapy for Prostate Cancer
Salvage therapy options for locally recurrent prostate cancer following radiotherapy failure include radical prostatectomy, brachytherapy, and cryotherapy. This study describes the results of the first effort at implementing percutaneous transperineal interstitial photodynamic therapy (PDT) and concludes that local control may be achievable with PDT if better light dosimetry is developed. -
Management of Invasive Carcinoma of the Uterine Cervix Associated with Pregnancy: Outcome in Intentional Delay in Treatment
Delay in treatment to allow for fetal maturity is safe in patients with early stage I cervical carcinoma associated with pregnancy. -
Rituximab for Relapsed Lymphoma after Autologous Transplant
In a retrospective review of treatment of patients with aggressive lymphoma who had relapsed after stem cell transplantation, single-agent rituximab was shown to induce complete or partial responses in close to 50% of patients. This compares favorably to salvage chemotherapy as reported in prior series. -
Fixed-Dose Single-Administration Pegfilgrastim vs Daily Filgrastim in Patients Receiving Myelosuppressive Chemotherapy
A single fixed dose of pegfilgrastim administered once per cycle of chemotherapy was comparable to multiple daily injections of filgrastim in safely providing neutrophil support during myelosuppressive chemotherapy. Pegfilgrastim may have use in other clinical settings of neutropenia. -
Gemcitabine Activity in Nasopoharyngeal Carcinoma
Type 2 nasopharyngeal carcinoma occurs most commonly in the Far East. However, patients with this tumor are being increasingly treated in North America with the increase in the number of Asian communities, particularly in urban areas. In this trial, patients with recurrent, locally advanced, or metastatic nasopharyngeal cancer who presented to a single institution for a 22-month period were treated with either gemcitabine alone or in combination with cisplatin. -
Clinical Briefs in Primary Care Supplement
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Pharmacology Watch: FDA Issues ‘Black Box’ Warning Based on WHI Study
The FDA has mandated a Black Box warning for all estrogen and estrogen/progestin products for use by postmenopausal women. The new warnings are based on analysis of data from the Womens Health Initiative (WHI) study that was published July 2002.